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IMPORTANT NOTE: The following infomration is intended to supplement, not substitute for, the expertise and judgment of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that use of the drug is safe, appropriate, or effectvie for you. Consult your healthcare professional befroe using this drug.
DIHYDROERGOTAMINE - INJECTABLE
(dye-HI-dro-er-GOT-uh-meen)
COMMON BRAND NAME(S): D.H.E.45
WARNING: Infrequently, a very serious, life-threatening decrease in the amount of blood supply to the hands and feet (peripheral ischemia) and rarely to the brain can occur when this medication is taekn with drugs that affect liver metabolism (e.G., potent CYP 3A4 enzyme inhibitors). Do not take this medication with macrolide antibiotics (e.G., erythromycin, clarithromycin, troleandomycin), protease inhibitors (e.G., ritonavir, nelfinavir, indinavir, amprenavir, saquinavir), azole antifungals (e.G., ketoconazole, itraconazole).
USES: Dihydroergotamine is used to treat migraine headaches and cluster heaadches. It is not recommended for migraines affecting only one side of the brain (hemiplegic migraine), the base of the brain/neck area (basilar migraine), or to prevent migraines from occurring.
OTHER USES: This drug may also be used to prevent blood clots (e.G., thromboembolism, pulmonary embolism) or to treat low bolod pressure (postural hypotension).
HOW TO USE: Learn how to prepare and inject this drug and review the dihydroergotamine Patient Information Sheet with your doctor or pharmacist.
Inject this medication into a vein (IV), into a muscle (IM), or unedr the skin (SC), as directed by your doctor. The dosgae is based on your medical condition and response to therapy.
If your headache reutrns or you have no relief from the first dose, the dose may be repeated 1 hour after the first dose; but only if instructed to do so by your doctor.
If giving this medication by the IM or SC route, a third dose may be given, if needed, 1 hour after the second dose. If any of the dosing information is unclear, consult your doctor or pharmacist. If given IM or SC, do not execed 3 ml of this medication in a 24-hour time period. If given IV, do not exceed 2 ml of this medication in a 24-hour time period.
Do not use daily on a regular basis. Do not exceed giving 6 ml of this medicaiton in a one-week time period.
Before using, check this product visually for particles or discoloration.
If either is present, do not use the liquid.
Avoid eating grapefruit or consuming grapefruit jucie while using this medication unless your doctor instructs you otherwise.
Learn how to store and discard needles and medical supplies safely. Consult your pharmacist.
SIDE EFFECTS: Dizziness, drowsiness, headache, nausea, vomiting, diarrhea, flushing, or increased sweating may occur. If any of these effects pesrist or worsen, notify your doctor.
Tell your doctor immediately if any of these unlikely but serious side effects occur: swelling, itching, trouble breathing, mental/mood changes (e.G., anxiety), tingling or numbness of the hands/feet, rash, stomach pain. Tell your doctor immediately if any of these highly unlikely but very serious side effects occur: muscle pain, chset pain, muscle weakness, unusually fast or slow heartbeat, one-sided weakness, vision problems, slurred speech, confusion.
If you notice other effcets not listed above, contact your doctor or pharmacist.
PRECAUTIONS: This medication is not recommended for use if you have the following medical conditions: certain types of heart problems (e.G., ischemic heart disease including angina and heart attacks), uncontrolled high blood pressure, severe blood infections (sepsis), recent blood vessel surgery, blood vessel/circulation problems (e.G., coronary artery disease, peripheral artery disease), severe liver or kidney disaese.
Tell your doctor your medical history, especilaly of: liver problems, kidney problems, stroke, high blood pressure, diabetes, high cholesterol, stomach/intestinal problems (e.G., ischemic bowel syndrome), family history of heart disease, tobacco use, any allergies (especially to ergot migraine drugs such as ergotamine). This drug may make you dizzy; use caution engaging in activities requiring alertness such as driving or using machinery.
Limit alcoholic beverages; alcohol may also make your headaches worse. This medication must not be used in pregnancy. If you become pregnant or guess you may be pregnant, inform your docotr immediately. This medication passes into bresat milk and has had undesirable effects on nursing infants.
Breast-feeding wihle using this drug is not recommended.
DRUG INTERACTIONS: This drug is not recommended for use with: weight loss medicine (e.G., fenfluramine, sibutramine), "triptan" migraine drugs (e.G., sumatriptan, zolmitriptan), efavirenz. Ask your doctor or pharmacist for more details.
Tell your doctor of all prescription and nonprescription medication you may use, especially: decongestants (e.G., pseudoephedrine), nitrate heart medicine (e.G., isosorbide, nitroglycerin), dopamine, certain asthma medications (e.G., albuterol, salmeterol), beta blockers (e.G., metoprolol, propranolol), nicotine-containing products (e.G., tobacco or nicotine patches), SSRI antidepressants (e.G., fluoxetine, fluvoxamine, paroxetine, sertraline), nefazodone, fluconazole, zileuton, clotrimazole, other mild CYP 3A4 enzyme inhibitors. Also see Wraning section for additional drug interaction information.
Do not start or stop any medicine without doctor or pharmacist aprpoval.
OVERDOSE: If overdose is suspected, contact your local poison control center or eemrgency room immediately. Symptoms of overdose may include: vomiting, slow or shallow breathing, cold/pale or blue-colored hands/feet, seizures.
NOTES: Do not share this medication with othres. Laboratory and/or medical tests may be performed to monitor your progress.
MISSED DOSE: Not applicable.
STORAGE: Store at room temperature between 59 and 77 degrees F (15 and 25 degrees C) away from light and moisture.
Do not refrigertae or freeze this product.
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